Greenville, South Carolina

Once a sleepy second fiddle to Southern culinary powerhouses like Charleston and Nashville, Greenville is stepping into the limelight with hot new restaurants. The town will soon be home to an outpost of Sean Brock's heirloom-crop-focused Husk and a food-centric market hall called the Commons. Other recent additions include modern Italian spot Jiannafrom Michael Kramer (the opening executive chef of McCrady's in Charleston, pre-Brock) and the moody speakeasy lounge Vault & Vator. It's an impressive collection of quality restaurants for a city of just over 67,000.

Those with a predilection for high-thread-count sheets will soon be able to luxuriate at the Grand Bohemian Hotel, a ritzy boutique property with Carolina charm. In the meantime, discerning visitors can bunk at the swank Westin Poinsett, a historic hotel that was rescued from the wrecking ball in the late '90s, laying the groundwork for Greenville’s great Southern revival.